Jonathan Richard Brewer

This study identifies a dUTPase from Mosigvirus AV110 that inhibits E. coli growth by disrupting DNA replication and cell division, revealing functional and evolutionary diversity among phage-encoded dUTP/dCTPases.

This study identifies Htm, a phage-encoded protein that reprograms the transcriptome of ESBL-E. coli to support phage replication by altering gene expression and metabolic pathways.

The paper identifies an antibacterial peptide from a phage that inhibits E. coli growth by disrupting Mre-dependent peptidoglycan synthesis.

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

This study uses patient-derived organoids to identify synaptic protein and phospho-regulatory deficits in schizophrenia.

This study develops a centrifugation protocol to isolate growth cones and immature synapses from human organoids, capturing synaptic development stages and enabling models for studying synaptic function and dysfunction.

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.

The paper identifies PAF15-PCNA assembly as a rate-limiting factor for lagging strand replication and replisome integrity, showing its regulation by the S-phase checkpoint.

This study presents a temporal atlas of protein and PTM abundance in cerebral organoids, showing significant changes during development related to neuronal differentiation and energy metabolism.

This study evaluates modified Nile Red dyes for super-resolution imaging of membrane packing in cells, finding differences in membrane structure between healthy and NPC1 disease fibroblasts.

The paper shows that zebra finches have high motor control resolution in vocal muscles, enabling precise control of birdsong through small motor unit sizes and low muscle stress.

This study shows that DHT can re-acquire high-quality songs in experienced canaries but not naive females, indicating hormonal modulation of song circuits changes with vocal practice.