Author

Patricia Lado‐Fernández

Universidade de Santiago de CompostelaORCID 0000-0002-3572-0257Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Manuel ColladoiD· 3 shared Jennifer A. MitchelliD· 2 shared Luis E. AbattiiD· 2 shared Miguel González‐BarciaiD· 2 shared Pablo PedrosaiD· 2 shared Sabela Da Silva‐ÁlvareziD· 2 shared Valentín Estévez‐SoutoiD· 2 shared Alejandro Failde-FiestrasiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

Manuel ColladoORCID

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3 papers

Recent·Most cited

Extracellular Vesicles from Senescent Tumor Cells Are Necessary and Sufficient to Drive Paracrine Senescence

Valentín Estévez‐Souto, Alex Miralles-Dominguez, Pablo Pedrosa, Patricia Lado‐Fernández, Miguel Angel Prados, Alejandro Failde-Fiestras, Raquel Paredes-Paredes, Jorge Ruz-Ortega, Marı́a José Alonso, Martina Migliavacca, Ester Polo, Rebeca Álvarez, Enrique Vázquez-De Luis, Ana Dopazo, Gabriela N. Condezo, , Sabela Da Silva‐Álvarez

This study shows that extracellular vesicles from senescent tumor cells are both necessary and sufficient to induce paracrine senescence in neighboring cells.

bioRxiv · Mar 27, 2026 · PreprintCancer Biology

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

Patricia Lado‐Fernández, Jéssica M. Vilas, Tânia Fernandes, Carmen Carneiro, Sabela Da Silva‐Álvarez, Valentín Estévez‐Souto, Pablo Pedrosa, Miguel González‐Barcia, Luis E. Abatti, Jennifer A. Mitchell, Carmen Rivas, Gema Moreno‐Bueno, Anxo Vidal, Manuel Collado

This paper shows that TP53 represses SOX2 in cancer cells, affecting cell identity and migration, with implications for metastasis in breast cancer.

International Journal of Cancer · Jun 2, 2025Peer-reviewedCancer Biology

Epigenetic reprogramming of a distal developmental enhancer cluster drives SOX2 overexpression in breast and lung cancer

Luis E. Abatti, Patricia Lado‐Fernández, Linh Huynh, Manuel Collado, Michael M. Hoffman, Jennifer A. Mitchell

The paper identifies an enhancer cluster that drives SOX2 overexpression in breast and lung cancer by altering chromatin accessibility and regulatory mechanisms.

Nucleic Acids Research · Aug 24, 2023Peer-reviewedGenomics