Author

Gema Moreno‐Bueno

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-5030-6687Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cancer & tumor microenvironment· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ignacio G. López-Cepero· 2 shared Macarena Morillo‐HuescaiD· 2 shared Mercedes ToméiD· 2 shared Raúl V. DurániD· 2 shared Sara S. OltraiD· 2 shared Alba Orantes· 1 shared Alberto HernándeziD· 1 shared Alexandra CortegosoiD· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Ignacio G. López-Cepero

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Circulating Immune Profiling Reveals Immune Signatures Associated with Disease Stage and Outcome in Endometrial Cancer

Raquel Piñeiro-Pérez, Ana Vilar, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Carmela Rodríguez, Alexandra Cortegoso, Raúl Márquez, Eva Díaz, Gema Moreno‐Bueno, Isabel Palacio, Sonia Blanco-Prieto, Lidia Maria Vazquez Tunas, Isaura Fernández, Ester Munera-Maravilla, , Laura Muinelo‐Romay

This study identifies immune signatures in circulating blood linked to disease stage and prognosis in endometrial cancer using flow cytometry.

The Journal of Liquid Biopsy · Sep 4, 2026Peer-reviewedCancer Biology

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

Patricia Lado‐Fernández, Jéssica M. Vilas, Tânia Fernandes, Carmen Carneiro, Sabela Da Silva‐Álvarez, Valentín Estévez‐Souto, Pablo Pedrosa, Miguel González‐Barcia, Luis E. Abatti, Jennifer A. Mitchell, Carmen Rivas, Gema Moreno‐Bueno, Anxo Vidal, Manuel Collado

This paper shows that TP53 represses SOX2 in cancer cells, affecting cell identity and migration, with implications for metastasis in breast cancer.

International Journal of Cancer · Jun 2, 2025Peer-reviewedCancer Biology

Asparagine endopeptidase promotes radioresistance in breast cancer through ATR pathway modulation

Macarena Morillo‐Huesca, Ignacio G. López-Cepero, Ryan Conesa-Bakkali, Mercedes Tomé, Colin K. W. Watts, Pablo Huertas, Gema Moreno‐Bueno, Raúl V. Durán, Jonathan Martínez‐Fábregas

This study identifies AEP's role in promoting radioresistance in breast cancer by modulating the ATR pathway and PPP1R10 levels, showing AEP-high/ATR-low as a biomarker for radioresistant patients.

Journal of Experimental & Clinical Cancer Research · Feb 26, 2025Peer-reviewedCancer Biology

FGFR1 inhibition prevents metabolic adaptation associated with therapy resistance in glioblastoma

Laura Zarzuela, Ignacio G. López-Cepero, Kevin M. Rattigan, Elena Sánchez-Escabias, Macarena Morillo‐Huesca, Ana Reina-Bando, Sara S. Oltra, Jesús María Sierra-Párraga, María Ceballos-Chávez, Vivian Capilla‐González, Gema Moreno‐Bueno, Piedad del Socorro Murdoch, José C. Reyes, G. Vignir Helgason, Mercedes Tomé, Raúl V. Durán

This study identifies FGFR1 as a key driver of TMZ resistance in GBM through metabolic rewiring and cell cycle regulation, showing that FGFR1 inhibition restores TMZ sensitivity in preclinical models.

bioRxiv · Jan 11, 2025 · PreprintCancer Biology

Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation

Isabel Tundidor, Marta Seijo-Vila, Sandra Blasco-Benito, María Rubert-Hernández, Gema Moreno‐Bueno, Laura Bîndilă, Rubén Fernández de la Rosa, Manuel Guzmán, Cristina Sánchez, Eduardo Pérez-Gómez

This study identifies FAAH as a key regulator of adult mammary gland development by promoting luminal cell differentiation through endocannabinoid signaling.

Cell Death Discovery · Jan 6, 2024Peer-reviewedDevelopmental Biology

Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells.

Sara S. Oltra, Sara Colomo, Laura Sin, María Pérez-López, Sara Lázaro, Ángela Molina-Crespo, Kyoung-Han Choi, David Ros‐Pardo, Lidia Martínez, Saleta Morales, Cristina González-Paramos, Alba Orantes, Mario Soriano‐Navarro, Alberto Hernández, Ana M. Lluch, , Gema Moreno‐Bueno

This study identifies how different GSDMB isoforms and protease cleavage regulate pyroptosis and mitochondrial damage in cancer cells.

Cell Death and Differentiation · Mar 10, 2023Peer-reviewedMolecular Biology