Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimers Disease-associated Genes
Matthew J. Moulton, Scott Barish, Isha Ralhan, Jinlan Chang, Lindsey D. Goodman, Jake G. Harland, Paul C. Marcogliese, Jan O. Johansson, Maria S. Ioannou, Hugo Jozef Bellen
This study identifies cell-specific roles of AD risk genes in ROS-induced glial lipid droplet formation and shows how their loss affects Aβ42 toxicity and plaque formation.
Proceedings of the National Academy of Sciences · Jan 1, 2021Peer-reviewedGenetics