Author

Isha Ralhan

University of AlbertaORCID 0000-0002-6890-2620Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jinlan ChangiD· 3 shared Maria S. IoannouiD· 3 shared Ju-Young Bae· 2 shared Nathanael Y.J. LeeiD· 2 shared Wendy Cai· 2 shared Alison D. Do· 1 shared Christopher J. Gerry· 1 shared Dawei ZhangiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Jinlan ChangORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 4, 2026

ApoE4 impairs astrocyte lipid droplet formation via endolysosomal dysfunction

Isha Ralhan, Ju-Young Bae, Nathanael Y.J. Lee…·Maria S. Ioannou

This study shows ApoE4 impairs astrocyte lipid droplet formation by disrupting endolysosomal function and demonstrates that PCSK9 can restore lipid droplet formation by preventing ApoE4 internalization.

DOI 10.64898/2026.09.01.748585

humanproteomics

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NeuroscienceNeuronPeer-reviewedDec 2, 2025

Protective ApoE variants support neuronal function by extracting peroxidated lipids

Isha Ralhan, Alison D. Do, Ju-Young Bae…·Maria S. Ioannou

The paper shows ApoE2 and ApoE3Ch variants protect neurons by removing toxic peroxidated lipids, while ApoE4 worsens lipid-induced damage in rodent models.

23 citationstop 1%

mouseexperimental assay

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GeneticsProceedings of the National Academy of SciencesPeer-reviewedJan 1, 2021

Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimers Disease-associated Genes

Matthew J. Moulton, Scott Barish, Isha Ralhan…·Hugo Jozef Bellen

This study identifies cell-specific roles of AD risk genes in ROS-induced glial lipid droplet formation and shows how their loss affects Aβ42 toxicity and plaque formation.

180 citationstop 1%

mouseDrosophila

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