Author

Cristoffer Sevilla

European Bioinformatics InstituteORCID 0000-0002-8570-4650Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:database / resource· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Guanming WuiD· 3 shared Karen RothfelsiD· 3 shared Lisa R. MatthewsiD· 3 shared Robin HawiD· 3 shared Bijay JassaliD· 2 shared Deidre BeaversiD· 2 shared Henning HermjakobiD· 2 shared Lincoln David SteiniD· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Guanming WuORCID

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3 papers

Recent·Most cited

Pathway-based, reaction-specific annotation of disease variants for elucidation of molecular phenotypes

Marija Orlic-Milacic, Karen Rothfels, Lisa R. Matthews, Adam Wright, Bijay Jassal, Veronica Shamovsky, Quang M. Trinh, Marc E. Gillespie, Cristoffer Sevilla, Krishna Kumar Tiwari, Eliot Ragueneau, Chuqiao Gong, Ralf Stephan, Bruce May, Robin Haw, , Guanming Wu

The paper annotates disease variants in the context of biological pathways to infer molecular phenotypes and model variant impacts.

Database · Jan 1, 2024Peer-reviewedSystems Biology

Illuminating Dark Proteins using Reactome Pathways

Timothy Brunson, Nasim Sanati, Lisa R. Matthews, Robin Haw, Deidre Beavers, Solomon I. Shorser, Cristoffer Sevilla, Guilherme Viteri, Patrick Conley, Karen Rothfels, Henning Hermjakob, Lincoln David Stein, Peter D’Eustachio, Guanming Wu

The paper predicts functional interactions of dark proteins with Reactome pathways using a random forest classifier and develops a web portal to visualize these interactions.

bioRxiv · Jun 5, 2023 · PreprintBioinformatics

COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms

Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert D. Phair, Aurelio Orta Resendiz, Vidisha Singh, Sara Sadat Aghamiri, Márcio Luís Acencio, Enrico Glaab, Andreas Ruepp, Gisela Fobo, Corinna Montrone, Barbara Brauner, Goar Frishman, , Özgün Babur

The paper describes the development of a computational knowledge repository, the COVID-19 Disease Map, which curates SARS-CoV-2 virus-host interaction mechanisms and provides tools for their analysis and application.

Molecular Systems Biology · Oct 1, 2021Peer-reviewedSystems Biology