In vivo chemical reprogramming is associated with a toxic accumulation of lipid droplets hindering rejuvenation
Wayne Mitchell, Cecília Gallottini de Magalhães, Alexander Tyshkovskiy, Yushi Uchida, Ludger J.E. Goeminne, Takaharu Ichimura, Emery L. Ng, Alibek Moldakozhayev, Joseph Vincent Bonventre, Vadim N. Gladyshev
This study shows that partial chemical reprogramming in aged mice increases lipid droplet formation, which may cause toxicity and hinder tissue rejuvenation.
Aging Cell · Jan 27, 2026Peer-reviewedCell Biology