Ludger J.E. Goeminne

In vivo chemical reprogramming is associated with a toxic accumulation of lipid droplets hindering rejuvenation

This study shows that partial chemical reprogramming in aged mice increases lipid droplet formation, which may cause toxicity and hinder tissue rejuvenation.

Integrative epigenetics and transcriptomics identify aging genes in human blood

This study identifies aging genes in human blood by integrating epigenetic and transcriptomic data, finding genes enriched for immune functions that better replicate across populations and link to aging outcomes.

A Unified Framework for Systematic Curation and Evaluation of Aging Biomarkers

The paper develops Biolearn, an open-source framework for curating and evaluating aging biomarkers across datasets, finding that harmonization and standardization improve their performance and generalizability.

Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials

The paper develops a cross-species proteomics pipeline to distinguish donor and host ECM proteins in explanted biomaterials, showing that single-species analysis leads to inaccurate quantification.

A compact protein panel for organ-specific age and chronic disease prediction

The paper identifies a compact panel of 21 plasma proteins that predict age-related diseases and organ health better than existing models and panels.

Plasma-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems

The paper uses machine learning on plasma proteome data to develop organ-specific and conventional aging models, showing that age-related diseases reflect accelerated aging of specific organs and systems.

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

This study uses multi-omics analysis to show that chemical reprogramming reduces biological age in mouse fibroblasts by altering metabolism and mitochondrial function.

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mice

This study examines how genetic background and sex influence metabolic responses to high-fat diet in mice, highlighting the role of mitochondrial function in physiological diversity.

Robust summarization and inference in proteome-wide label-free quantification

This paper introduces MSqRob-Sum, a novel summarization strategy for proteome-wide label-free quantification that maintains the performance of MSqRob while enabling protein-level analysis and reducing computational demands.

MSqRob takes the missing hurdle: uniting intensity- and count-based proteomics

The paper introduces a hurdle model to address missing values in proteomics by combining binomial count and intensity-based components, showing improved performance over existing methods.