This study uses metagenomics and metabolomics to show age-related gut microbiota and metabolite changes in hamsters with experimental COVID-19, linking them to disease severity and recovery.

Gut Microbes · Apr 2, 2025Peer-reviewedImmunology

Major Metabolites From Hypericum perforatum L., Hyperforin And Hypericin, Are Both Active Against Human Coronaviruses

Imelda Raczkiewicz, Céline Rivière, Peggy Bouquet, Lowiese M. B. Desmarets, Audrey Tarricone, Charline Camuzet, Nadine François, Guillaume Lefèvre, Jennifer Samaillie, F. Silva Angulo, Cyril Robil, François Trottein, Sevser Şahpaz, J. D. Dubuisson, Sandrine Belouzard, , Karin Séron

This study shows that hyperforin from Hypericum perforatum inhibits multiple coronaviruses, including SARS-CoV-2, with antiviral activity confirmed in human cells and potential for combination therapy with remdesivir.

bioRxiv · Apr 9, 2024 · PreprintMicrobiology

The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis

Florent Sauvé, Sreekala S. Nampoothiri, Sophie A. Clarke, Daniela Fernandois, Caio Fernando Ferreira Coêlho, Julie Dewisme, Edouard Mills, Gaëtan Ternier, Ludovica Cotellessa, Cristina Iglesias, Helge Müller‐Fielitz, Thibaud Lebouvier, Romain Perbet, V. Florent, Marc Baroncini, , Vincent Prévot

The paper investigates SARS-CoV-2 infection in the hypothalamus and associated regions, showing viral entry receptors and susceptibility factors linked to neurological symptoms in COVID-19.

EBioMedicine · Sep 13, 2023Peer-reviewedNeuroscience