François Trottein

This study identifies cis-aconitate as a dual-action antiviral and anti-inflammatory agent that reduces influenza mortality in mice by targeting viral polymerase and ERK/AKT/NF-κB signaling.

This study uses metaproteomics to identify age-specific changes in the gut microbiome of SARS-CoV-2-infected hamsters, revealing functional alterations and host-microbiome interactions.

This study uses metagenomics and metabolomics to show age-related gut microbiota and metabolite changes in hamsters with experimental COVID-19, linking them to disease severity and recovery.

This study shows that hyperforin from Hypericum perforatum inhibits multiple coronaviruses, including SARS-CoV-2, with antiviral activity confirmed in human cells and potential for combination therapy with remdesivir.

The paper identifies PD-L1+ neutrophils in severe viral respiratory infections, showing they have regulatory functions and are generated in the bone marrow via IFN-γ.

The paper investigates SARS-CoV-2 infection in the hypothalamus and associated regions, showing viral entry receptors and susceptibility factors linked to neurological symptoms in COVID-19.