BiochemistrySciencePeer-reviewed
Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control
Daniel B. Grabarczyk, Julian F. Ehrmann, Paul V. Murphy…·Tim Clausen
The paper presents the cryo-EM structure of the UBR4 complex, revealing its architecture and mechanism for substrate binding and ubiquitin chain extension in protein quality control.
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