Author

Daniel B. Grabarczyk

Research Institute of Molecular PathologyORCID 0000-0003-0216-7085Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Gijs A. VersteegiD· 3 shared Julian F. EhrmanniD· 3 shared Tim ClauseniD· 3 shared Alexandra ShulkinaiD· 2 shared Kathrin Hacker· 2 shared Valentina BudroniiD· 2 shared Alexander SchleifferiD· 1 shared Anton MeinhartiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCell Biology

Gijs A. VersteegORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedJan 19, 2026

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.

Irene Schwartz, Valentina Budroni, Mathilde Meyenberg…·Gijs A. Versteeg

The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.

9 citationstop 3%

humanproteomics

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BiochemistrySciencePeer-reviewedAug 28, 2025

Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control

Daniel B. Grabarczyk, Julian F. Ehrmann, Paul V. Murphy…·Tim Clausen

The paper presents the cryo-EM structure of the UBR4 complex, revealing its architecture and mechanism for substrate binding and ubiquitin chain extension in protein quality control.

20 citationstop 3%

experimental assayprotein folding & dynamics

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Molecular BiologybioRxivPreprintMay 16, 2024

TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligases

Alexandra Shulkina, Kathrin Hacker, Julian F. Ehrmann…·Gijs A. Versteeg

The paper identifies TRIM52 as a primate-specific DNA repair factor under tight proteolytic control by BIRC6, HUWE1, and UBR4/KCMF1.

2 citations

humanproteomics

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