Author

Alexandra Shulkina

University of ViennaORCID 0009-0008-4266-2789Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Daniel B. GrabarczykiD· 2 shared Gijs A. VersteegiD· 2 shared Julian F. EhrmanniD· 2 shared Tim ClauseniD· 2 shared Alexander SchleifferiD· 1 shared Anton MeinhartiD· 1 shared Ariane MandlbaueriD· 1 shared Eszter ZavodszkyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

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10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

Daniel B. GrabarczykORCID

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2 papers

Recent·Most cited

BiochemistrySciencePeer-reviewedAug 28, 2025

Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control

Daniel B. Grabarczyk, Julian F. Ehrmann, Paul V. Murphy…·Tim Clausen

The paper presents the cryo-EM structure of the UBR4 complex, revealing its architecture and mechanism for substrate binding and ubiquitin chain extension in protein quality control.

20 citationstop 3%

experimental assayprotein folding & dynamics

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMay 16, 2024

TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligases

Alexandra Shulkina, Kathrin Hacker, Julian F. Ehrmann…·Gijs A. Versteeg

The paper identifies TRIM52 as a primate-specific DNA repair factor under tight proteolytic control by BIRC6, HUWE1, and UBR4/KCMF1.

2 citations

humanproteomics

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