Author

Valeriy G. Ostapchenko

Western UniversityORCID 0000-0002-3629-7702Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

Marco A. M. PradoiD· 2 shared Aja E. Hogan-CanniD· 1 shared Diana Yae Sakae· 1 shared Evan CalabreseiD· 1 shared Flávio H. BeraldoiD· 1 shared G. Allan JohnsoniD· 1 shared Gábor TuruiD· 1 shared Gabriel IchimiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Marco A. M. PradoORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Measuring nonapoptotic caspase activity with a transgenic reporter in mice

PETER J. NICHOLLS, Thomas F. Pack, Nikhil M. Urs, Sunil Kumar, Yang Zhou, Gabriel Ichim, Joshua D. Ginzel, Gábor Turu, Evan Calabrese, Wendy L. Roberts, Ping Fan, Valeriy G. Ostapchenko, Monica S. Guzman Lenis, Flávio H. Beraldo, Jiřı́ Hatina, , Marc G. Caron

The paper develops a transgenic mouse model with a fluorescent caspase activity reporter to quantify nonapoptotic caspase activity in rodent brains and demonstrates its use in studying neurophysiological and stress-related effects.

eNeuro · Sep 1, 2022Peer-reviewedNeuroscience

Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice

William Binning, Aja E. Hogan-Cann, Diana Yae Sakae, Matthew Maksoud, Valeriy G. Ostapchenko, Mohammed Al‐Onaizi, Sara Matovic, Wei-Yang Lu, Marco A. M. Prado, Wataru Inoue, Vânia F. Prado

This study shows that chronic activation of hM3Dq in microglia reduces neuroinflammation and sickness behavior in mice by modulating cytokine responses.

Brain Behavior and Immunity · May 17, 2020Peer-reviewedNeuroscience