Author

Yijia Chen

University of PittsburghORCID 0000-0001-7033-9593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Alyson WangiD· 2 shared Amanda C. PoholekiD· 2 shared Jishnu DasiD· 2 shared Aileen Tian· 1 shared Alisa A. OmelchenkoiD· 1 shared Alison R. MilleriD· 1 shared Chinmay V. Gadiraju· 1 shared Dafne Díaz-RiveraiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Alyson WangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A unified network systems approach uncovers a core novel program underlying T follicular helper cell differentiation

Alisa A. Omelchenko, Syed Ashiqur Rahman, Alyson Wang, Tracy Tabib, Vinay Viswanadham, Grace J. Yuen, Perla M. Del Río Estrada, Valentino D’Onofrio, Yijia Chen, Na Sun, Hamid Mattoo, Swapnil Keshari, Chinmay V. Gadiraju, Gonzalo Salgado Montes de Oca, Maribel Soto-Nava, , Jishnu Das

This study identifies a core gene program underlying Tfh cell differentiation using a multi-scale network systems approach, revealing a novel role for IL-12 in regulating Tfh precursor differentiation.

Nature Communications · Jul 22, 2026Peer-reviewedImmunology

Characterizing spatial functional microniches with SpaceTravLR

Koushul Ramjattun, Alyson Wang, Hannah J. Lee, Shilpi Giri, Yijia Chen, William A. MacDonald, Nathan D. Lord, Amanda C. Poholek, Youjin Lee, Jishnu Das

SpaceTravLR identifies spatial functional microniches by modeling genetic perturbations across spatially resolved molecular networks, validated experimentally in a murine model.

bioRxiv · Nov 13, 2025 · PreprintSystems Biology

From Wiring to Firing: Collapse of embryonic identities and emergence of functional diversity during motor neuron maturation

Yijia Chen, Hsuan-Ming Chi, Aileen Tian, Alison R. Miller, Tulsi Patel

This study tracks the transcriptional and chromatin changes in mouse motor neurons during maturation, revealing dynamic shifts in diversity and functional identity.

bioRxiv · Aug 12, 2025 · PreprintNeuroscience