David G. DeNardo

The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.

This study identifies TAK1 as a therapeutic target in pancreatic cancer that enhances anti-tumor immunity and sensitizes tumors to checkpoint blockade.

The paper introduces a framework for mathematical modeling of multicellular systems using interpretable cell behavior rules derived from biological knowledge and multi-omics data.

M3NetFlow is a multi-scale multi-hop graph model for multi-omic data analysis that ranks targets and infers signaling pathways, achieving high accuracy in drug response and Alzheimer's disease studies.

SC2MeNetDrug is a tool that identifies cell-cell signaling targets and predicts drugs using scRNA-seq data to analyze disease microenvironments.

Ibex vectorizes BCR sequences for dimensional reduction and integrates into single-cell analysis workflows.