Author

Timothy Hung-Po Chen

Washington University in St. LouisORCID 0000-0002-3553-9714Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Avinash RamuiD· 1 shared Brett L. KnolhoffiD· 1 shared Christopher A. MaheriD· 1 shared David G. DeNardoiD· 1 shared Douglas R. AdkinsiD· 1 shared Emily B. RozyckiiD· 1 shared Gavin P. DunniD· 1 shared Huiming XiaiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBioinformatics

Avinash RamuORCID

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2 papers

Recent·Most cited

Targeting Tumor-intrinsic TAK1 triggers anti-tumor immunity and sensitizes pancreatic cancer to checkpoint blockade

Sapana Bansod, Timothy Hung-Po Chen, Vikas Somani, Lin Li, Suneeta Modekurty, Brett L. Knolhoff, Ryan Courtney Fields, Marianna B. Ruzinova, David G. DeNardo, Kian‐Huat Lim

This study identifies TAK1 as a therapeutic target in pancreatic cancer that enhances anti-tumor immunity and sensitizes tumors to checkpoint blockade.

bioRxiv · Oct 8, 2025 · PreprintCancer Biology

RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer

Kelsy C. Cotto, Yang-Yang Feng, Avinash Ramu, Megan M. Richters, Sharon L. Freshour, Zachary L. Skidmore, Huiming Xia, Joshua F. McMichael, Jason Kunisaki, Katie Marie Campbell, Timothy Hung-Po Chen, Emily B. Rozycki, Douglas R. Adkins, Siddhartha H. K. Devarakonda, Sumithra Sankararaman, , Malachi Griffith

RegTools identifies splice-associated variants in cancer by integrating genomic and transcriptomic data across 9,000 tumor samples, discovering 235,778 splicing events.

Nature Communications · Mar 22, 2023Peer-reviewedBioinformatics