Siling Du

The paper shows that CNS macrophage engraftment depends on TRM self-renewal and niche timing, not prolonged vacancy, and identifies a peripheral BAM-like macrophage population in aged human brains.

The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.

The paper identifies two distinct pathways for replenishing resident peritoneal macrophages after injury, with differing reliance on monocytes and intermediate stages.

The paper identifies amino acids critical for tau strain propagation by analyzing their role in amyloid templating across different tauopathies.