Jonathan R. Brestoff

Inflammaging in aged tissues drives remodeling of the CD8+ T cell compartment

This study shows that inflammaging in aged tissues drives the development of age-associated CD8+ T cells through adipose tissue niches.

Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts

The paper shows immune cells regulate circulating adipocyte extracellular vesicle levels by clearing EVs, with reduced clearance in obesity leading to increased circulating adipoEVs.

Electron microscopy visualization of cell-free mitochondrial DNA-containing extracellular vesicles in human plasma, serum, and saliva

The paper uses electron microscopy to analyze mitochondrial DNA-containing extracellular vesicles in human biofluids, showing that cf-mtDNA is often associated with double-membrane particles.

Multiplexed quantum sensing reveals coordinated thermomagnetic regulation of mitochondria

This study uses quantum sensors to show that mitochondria in mouse cells regulate temperature and magnetic fields through iron-dependent feedback loops, with altered profiles in a Leigh syndrome model.

MXRA8 promotes adipose tissue whitening to drive obesity

This study identifies MXRA8 as a promoter of adipose tissue whitening that drives obesity, showing its role in reducing UCP1 expression and protecting against obesity in mice.

Ibex: Variational autoencoder for single-cell BCR sequencing.

Ibex vectorizes BCR sequences for dimensional reduction and integrates into single-cell analysis workflows.