Joshua X. Yee

This study shows that HIV-1 DNA/rAd5 vaccination leads to distinct clonal expansion and memory precursor states in Env- and Gag-specific CD8 T cells.

The paper identifies distinct functional roles of VTA dopamine subpopulations in reward association and motivation using electrophysiology and optogenetics in mice.

The paper uses optogenetic stimulation and single-nucleus RNA sequencing to identify input-specific activation patterns of VTA neuronal subpopulations and their immediate early gene programs.

This study shows that Kv4.3 and BKCa1.1 ion channels regulate dopamine neuron firing and release on different time scales, influencing distinct phases of reinforced behavior in mice.

The paper demonstrates how stimulatory neuropeptide and inhibitory neurotransmitter signals work together in a neural circuit to enhance dopamine neuron activation and optimize behavioral reinforcement.