Author

Guoyue Xu

Fred Hutch Cancer CenterORCID 0000-0002-7699-8837Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:clustering· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

David Richard GlassiD· 2 shared Ernest MoelhmaniD· 2 shared Evan William NewelliD· 2 shared Abhai Tripathi· 1 shared Anastasia A. MinervinaiD· 1 shared Andrew J. CowaniD· 1 shared Andrew J. Fiore-GartlandiD· 1 shared Arnab Ashrafi· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

David Richard GlassORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

HIV-1 prime-boost vaccination shapes distinct clonal trajectories and memory precursor states of Env- and Gag-specific T cells

Guoyue Xu, Joshua X. Yee, Saskia Ilcisin, N Kaul, Koshlan Mayer-Blackwell, Ernest Moelhman, David Richard Glass, Anastasia A. Minervina, Shelly Karuna, Magdalena E. Sobieszczyk, Matthew R. Hart, Paul Glyndwr Thomas, Peter J. Skene, Stephen C. De Rosa, M. Juliana McElrath, , Evan William Newell

This study shows that HIV-1 DNA/rAd5 vaccination leads to distinct clonal expansion and memory precursor states in Env- and Gag-specific CD8 T cells.

bioRxiv · Sep 29, 2026 · PreprintImmunology

The CCCH-type zinc-finger PfMD3 promotes translation for malaria parasite transmission

Riette Van Biljon, Suyash Bhatnagar, Rajat Kumar, Megan L. Gliozzi, Guoyue Xu, Abhai Tripathi, Arnab Ashrafi, Kristian E. Swearingen, Photini Sinnis, Manuel Llinás, Heather J. Painter

This study identifies PfMD3 as an RNA-binding protein that regulates male gamete fertility by impacting translation in Plasmodium falciparum.

bioRxiv · May 28, 2026 · PreprintMolecular Biology

Hallmarks of tumor-experienced T cells are absent in multiple myeloma patients from diagnosis through maintenance therapy

Carolyn Shasha, David Richard Glass, Ernest Moelhman, Laura Islas, Yuan Tian, Tony Chour, Guoyue Xu, Gregory Lee Szeto, Tao Peng, Xiaoling Song, Michelle A. Wurscher, Andrew J. Cowan, Thomas F. Bumol, Troy R. Torgerson, Philip D. Greenberg, , Evan William Newell

The paper profiles CD8+ T cells in multiple myeloma patients to assess tumor reactivity and exhaustion, finding no evidence of tumor-experienced T cells with hallmark exhaustion or activation features.

Blood · Mar 31, 2025Peer-reviewedImmunology