Jessica Hellinger

The paper develops a fluorescent reporter, SeARCh, to quantify selenocysteine incorporation and reports a hybrid biosynthetic pathway achieving 90% Sec incorporation.

The paper identifies mutations in smURFP that significantly increase in vivo fluorescence in E. coli through deep mutational scanning and biophysical analysis.

This paper develops a L-DOPA sensing system and improves biosynthesis via directed evolution, achieving high-efficiency incorporation into proteins.