Karen Moore

Developmental priming increases copper-tolerance in a model fish species via epigenetic-and microbiome-mediated mechanisms

This study shows that developmental priming with low copper exposure increases copper tolerance in stickleback fish through epigenetic and microbiome changes.

The genomic signature and transcriptional response of metal tolerance in brown trout inhabiting metal-polluted rivers

This study investigates the genomic and transcriptomic signatures of metal tolerance in brown trout from metal-polluted rivers, identifying genetic and gene expression changes associated with metal resistance.

Long-read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathology

The paper uses long-read transcript sequencing to identify differential isoform expression in the entorhinal cortex of tau transgenic mice, revealing novel isoforms and transcript associations with tau pathology.

Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex

This study uses long-read RNA sequencing to analyze isoform diversity in human and mouse cerebral cortex, revealing widespread alternative splicing and novel transcripts.

Long-read viral metagenomics enables capture of abundant and microdiverse viral populations and their niche-defining genomic islands

The paper introduces VirION, a long-read sequencing method for viral metagenomics that improves genome assembly and captures microdiverse viral populations and genomic islands.

Transcriptional signatures of progressive neuropathology in transgenic tau and amyloid mouse models.

This study identifies transcriptional changes in tau and amyloid mouse models, revealing gene expression patterns linked to AD pathology and immune response.

A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortex

This study identifies widespread H3K27ac acetylomic variation in AD cases compared to controls, linking it to disease-related pathways and AD-associated genetic variants.