Author

Matouš Vobořil

Czech Academy of SciencesORCID 0000-0002-3672-7629Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Adéla ČepkováiD· 1 shared Bernard MALISSENiD· 1 shared David MachaciD· 1 shared Dominik FilippiD· 1 shared Evgeny ValteriD· 1 shared Fernando Bandeira SulczewskiiD· 1 shared Graham AndersoniD· 1 shared Jan ČernýiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

Adéla ČepkováORCID

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2 papers

Recent·Most cited

Thymic DC2 are heterogenous and include a novel population of transitional dendritic cells

Matouš Vobořil, Fernando Bandeira Sulczewski, Ryan J. Martinez, Katherine Maude Ashby, Michael Manoharan Valerio, Juliana Idoyaga, Kristin Ann Hogquist

The paper identifies four distinct lineages within previously classified thymic DC2, including monocyte-derived DCs and a novel transitional DC population, revealing heterogeneity in thymic myeloid cell development.

bioRxiv · Jun 13, 2025 · PreprintImmunology

Claudin 1-mediated positioning of DC1 to mTECs is essential for antigen transfer-coupled DC1 maturation and maintenance of central tolerance

Jiří Březina, Tomáš Brabec, David Machac, Matouš Vobořil, Ondřej Ballek, Jan Pačes, Vojtěch Sýkora, Kristina Jancovicova, Evgeny Valter, Katarina Kovacova, Jasper E. Manning, Valerie Tahtahova, Adéla Čepková, Martina Dobešová, Jan Dobeš, , Dominik Filipp

The study identifies Claudin 1 on DC1s as essential for their positioning near mTECs, facilitating antigen transfer and DC1 maturation, which maintains central tolerance.

bioRxiv · Mar 15, 2025 · PreprintImmunology