Author

Jan Dobeš

Charles UniversityORCID 0000-0003-1853-1603Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Tomáš BrabeciD· 2 shared Adéla ČepkováiD· 1 shared Afshan IqbaliD· 1 shared Anna Maria FrontinoiD· 1 shared Bernard MALISSENiD· 1 shared Daniel V. OliveiraiD· 1 shared David MachaciD· 1 shared Dominik FilippiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Tomáš BrabecORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintMar 15, 2025

Claudin 1-mediated positioning of DC1 to mTECs is essential for antigen transfer-coupled DC1 maturation and maintenance of central tolerance

Jiří Březina, Tomáš Brabec, David Machac…·Dominik Filipp

The study identifies Claudin 1 on DC1s as essential for their positioning near mTECs, facilitating antigen transfer and DC1 maturation, which maintains central tolerance.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

Developmental BiologybioRxivPreprintOct 24, 2022

Jag1 Insufficiency Disrupts Neonatal T Cell Differentiation and Impairs Hepatocyte Maturation, Leading to Altered Liver Fibrosis

Jan Mašek, Iva Filipovic, Noémi Van Hul…·Emma Rachel Andersson

This study shows that Jag1 deficiency in a mouse model of Alagille syndrome leads to impaired liver fibrosis due to defective T cell differentiation and hepatocyte maturation.

DOI 10.1101/2022.10.24.513578

mousebulk RNA-seq

𝕏 PostBluesky