Author

Jan Pačes

Charles UniversityPrimary ORCID profile (0000-0003-3059-6127 · 5 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Jan PačesiD5 papers · Czech Academy of Sciences

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Adéla ČepkováiD· 1 shared Bernard MALISSENiD· 1 shared David MachaciD· 1 shared Dominik FilippiD· 1 shared Evgeny ValteriD· 1 shared Graham AndersoniD· 1 shared Jan ČernýiD· 1 shared Jan DobešiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Adéla ČepkováORCID

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1 paper

Recent·Most cited

Claudin 1-mediated positioning of DC1 to mTECs is essential for antigen transfer-coupled DC1 maturation and maintenance of central tolerance

Jiří Březina, Tomáš Brabec, David Machac, Matouš Vobořil, Ondřej Ballek, Jan Pačes, Vojtěch Sýkora, Kristina Jancovicova, Evgeny Valter, Katarina Kovacova, Jasper E. Manning, Valerie Tahtahova, Adéla Čepková, Martina Dobešová, Jan Dobeš, , Dominik Filipp

The study identifies Claudin 1 on DC1s as essential for their positioning near mTECs, facilitating antigen transfer and DC1 maturation, which maintains central tolerance.

bioRxiv · Mar 15, 2025 · PreprintImmunology