Jérôme Golebiowski

Elucidating the structural basis for ligand binding and translocation in conserved insect odorant receptor co-receptors

The paper identifies amino acids involved in ligand entry and binding to Drosophila Orco using molecular modeling and electrophysiology, revealing a mechanism for ligand translocation and high selectivity.

Extracellular loop 2 of G protein-coupled olfactory receptors is critical for odorant recognition

This study shows that ECL2 in GPCRs is crucial for odorant recognition and promiscuity, enabling virtual screening of ligands with high success.

Functional Molecular Switches of Mammalian G Protein-Coupled Bitter-Taste Receptors

The paper improves comparative modeling of mammalian bitter-taste receptors (TAS2Rs) by re-aligning sequences and constructing homology models, validated through site-directed mutagenesis and functional assays.

Molecular insights into the μ-opioid receptorselective signaling

The paper investigates how opioid ligands selectively activate G protein over β-arrestin pathways in the μ-opioid receptor using a combination of experimental and computational methods.

Functions of olfactory receptors are decoded from their sequence

The paper uses machine learning to predict olfactory receptor-odorant pairs and basal activity from sequence data, identifying key residues that determine selectivity and activity.