Jérémie Topin

The paper identifies a single amino acid mutation in an odorant receptor that increases sensitivity to host plant volatiles in the lily moth Spodoptera picta.

The paper presents an ensemble model that improves predictions of perceptual similarity between odor mixtures using a curated dataset and collaborative challenge results.

This paper applies structure-based virtual screening to insect odorant receptors to accelerate ligand discovery, identifying new behaviorally active volatiles for non-pheromonal receptors.

The paper identifies amino acids involved in ligand entry and binding to Drosophila Orco using molecular modeling and electrophysiology, revealing a mechanism for ligand translocation and high selectivity.

This study shows that ECL2 in GPCRs is crucial for odorant recognition and promiscuity, enabling virtual screening of ligands with high success.

The paper improves comparative modeling of mammalian bitter-taste receptors (TAS2Rs) by re-aligning sequences and constructing homology models, validated through site-directed mutagenesis and functional assays.