Xiaojing Cong

This study presents cryo-EM structures of RXFP1 bound to relaxin-2 and AZD5462, revealing distinct activation mechanisms for protein and small-molecule agonists.

This paper develops a photoswitchable positive allosteric modulator of mGlu5 that activates the receptor in response to light, demonstrating reversible isomerization and light-dependent activity.

This study shows that ECL2 in GPCRs is crucial for odorant recognition and promiscuity, enabling virtual screening of ligands with high success.

The paper investigates how opioid ligands selectively activate G protein over β-arrestin pathways in the μ-opioid receptor using a combination of experimental and computational methods.

The paper uses machine learning to predict olfactory receptor-odorant pairs and basal activity from sequence data, identifying key residues that determine selectivity and activity.