Author

Jonathan A. Fine

Purdue University West LafayetteORCID 0000-0002-3685-8581Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Gaurav ChopraiD· 3 shared Ahad Hossain· 1 shared Alexis Crockett· 1 shared Anxhela GjojdeshiiD· 1 shared Bin DongiD· 1 shared Caitlin E. RandolphiD· 1 shared Chi ZhangiD· 1 shared Daniela Allende· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioinformatics

Gaurav ChopraORCID

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3 papers

Recent·Most cited

Amyloid beta Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer's Disease

Priya Prakash, Palak Manchanda, Evangelia Paouri, Kanchan Bisht, Kaushik P. Sharma, Jitika Rajpoot, Victoria Wendt, Ahad Hossain, Prageeth R. Wijewardhane, Caitlin E. Randolph, Yihao Chen, Sarah Stanko, Nadia Gasmi, Anxhela Gjojdeshi, Sophie Card, , Gaurav Chopra

This study identifies lipid droplet formation in microglia as a mechanism linking amyloid-beta exposure to impaired phagocytosis in Alzheimer's disease, with DGAT2 as a therapeutic target.

Alzheimer s & Dementia · Dec 1, 2023Peer-reviewedNeuroscience

DUBS: A Framework for Developing Directory of Useful Benchmarking Sets for Virtual Screening

Jonathan A. Fine, Matthew Muhoberac, Guillaume Fraux, Gaurav Chopra

DUBS provides a framework to create standardized benchmarking sets for virtual screening using a simple input format and the Lemon data mining framework.

Journal of Chemical Information and Modeling · Jul 8, 2020Peer-reviewedBioinformatics

Lemon: a framework for rapidly mining structural information from the Protein Data Bank

Jonathan A. Fine, Gaurav Chopra

Lemon provides a fast framework to mine structural features from the PDB by parsing and analyzing 3D biomolecular data efficiently.

Bioinformatics · Mar 13, 2019Peer-reviewedBioinformatics