Targeting DNMT1 augments anti-tumor CD8⁺ T cell function
Maya G. Deshmukh, Danielle K. Sohai, Kamal Obbad, Koonam Park, Simon Milette, Peili Gu, Henna S. Nam, Andrew J. Daniels, Krasimir A. Spasov, Michael E. Hurwitz, Samuel G. Katz, Richard Anthony Flavell, Karen S. Anderson, Marcus Bosenberg, Goran Micevic
This study shows that inhibiting DNMT1 improves CD8+ T cell function in the tumor microenvironment and enhances the effectiveness of immune checkpoint inhibitors in a melanoma model.
bioRxiv · Jul 6, 2026 · PreprintImmunology