Hiroshi Suemizu

This paper identifies vorapaxar and aripiprazole as inhibitors of HBV replication through distinct host signaling pathways, showing their potential as host-targeting antivirals.

The paper reports a method to reprogram primary human hepatocytes into proliferative pre-cHep cells with high expansion potential and liver repopulation capacity, offering an alternative to PHHs for drug testing and disease modeling.

This study develops a method to generate functional hepatocytes from human pluripotent stem cells through controlled differentiation and tissue engineering.

The paper identifies functionally conserved lncRNA metabolic regulators in human and mouse livers that regulate triglyceride levels through a shared mechanism involving PABPC1 binding.

This paper uses a humanized mouse model and Nanopore sequencing to study metabolic responses in human liver transcriptomes, revealing novel transcripts, regulatory pathways, and dynamic RNA modifications.