Author

Luke Xie

GenentechORCID 0000-0002-3712-5558Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Hai NguiD· 2 shared Jesse E. HansoniD· 2 shared Oded ForemaniD· 2 shared Tiffany Z. WuiD· 2 shared Alyaa M. Abdel‐HaleemiD· 1 shared Brad A. FriedmaniD· 1 shared Caspar GlockiD· 1 shared Daqi Xu· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersNeuroscience

Hai NguORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 16, 2025

Complement C3aR deletion does not attenuate neurodegeneration in a tauopathy model or alter acute inflammation-induced gene expression changes in the brain

Yuanyuan Wang, Shristi Pandey, Martin Weber…·Jesse E. Hanson

This study shows that deleting C3aR does not reduce neurodegeneration in a tauopathy model or alter gene expression changes during acute inflammation.

3 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeuroscienceeLifePeer-reviewedJul 31, 2023

TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

Yuanyuan Wang, Tiffany Z. Wu, Ming‐Chi Tsai…·Jesse E. Hanson

This study shows that TPL2 kinase activity in microglia drives neuroinflammation and neurodegeneration in tauopathy models, suggesting it as a therapeutic target.

16 citations

mousebulk RNA-seq

𝕏 PostBluesky