Caspar Glock

Soma-seq measures both RNA and intracellular proteins in single human brain cells, revealing protein states linked to transcriptional programs in Alzheimer's disease.

This study shows that TPL2 kinase activity in microglia drives neuroinflammation and neurodegeneration in tauopathy models, suggesting it as a therapeutic target.

The paper identifies and quantifies the transcriptome and translatome in neuronal cell bodies, dendrites, and axons using RNA-seq and Ribo-seq, revealing that local translation is a major source of synaptic proteins.

The paper shows that monosomes, not polysomes, are the main sites of active translation for synaptic mRNAs in neuronal processes, contributing to local protein synthesis.

This study shows that Pabpn1 regulates polyadenylation of synaptic plasticity genes and affects homeostatic plasticity in neurons.