Debra Rimmington

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.

The paper uses single-nucleus RNA sequencing to analyze the mouse hindbrain's AP and NTS in fed and fasted states, identifying transcriptional changes and receptor expression patterns relevant to obesity therapies.

The paper uses single-cell RNA sequencing to reveal heterogeneity in murine hypothalamic POMC neurons, identifying distinct subpopulations with different gene expression profiles and receptor expression.