Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causingautoimmune diseases through autoantibody production
Kazumasa Suzuki, Leo J. Arteaga-Vazquez, Bruno Villalobos Reveles, Lot Hernández-Espinosa, Isaac F. López-Moyado, Atsushi Onodera, Daniela Samaniego‐Castruita, Ferhat Ay, Arlet Lara-Custodio, Patrick G. Hogan, Hugo Sepúlveda, Anjana Rao
This study shows that loss of TET function in Treg cells leads to ex-Treg cells that differentiate into Tfh cells, promoting autoantibody production and autoimmune disease.
bioRxiv · Aug 29, 2025 · PreprintImmunology