Kazumasa Suzuki

TET loss of function selects for aneuploidies that confer a proliferative advantage

This study shows that TET loss of function promotes aneuploidy, particularly chromosome 17 trisomy, which provides a proliferative advantage in iNKT cells and mESCs.

Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causingautoimmune diseases through autoantibody production

This study shows that loss of TET function in Treg cells leads to ex-Treg cells that differentiate into Tfh cells, promoting autoantibody production and autoimmune disease.

Distinct interferon response patterns link to increased transposable element expression in leukocytes of systemic lupus erythematosus patients

This study links increased transposable element (TE) expression in SLE patients to IFN responses, showing strong correlations with disease activity and splicing alterations.