Isaac F. López-Moyado

TET loss of function selects for aneuploidies that confer a proliferative advantage

This study shows that TET loss of function promotes aneuploidy, particularly chromosome 17 trisomy, which provides a proliferative advantage in iNKT cells and mESCs.

Flanking DNA sequences determine DNA methylation maintenance in proliferation, cancer and aging

The paper identifies DNA hexanucleotide sequences that determine DNA methylation maintenance across cell divisions, revealing their role in biological age and cancer progression.

Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causingautoimmune diseases through autoantibody production

This study shows that loss of TET function in Treg cells leads to ex-Treg cells that differentiate into Tfh cells, promoting autoantibody production and autoimmune disease.

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

This study shows that OGT inhibits TET activity, preventing DNA demethylation and transposable element expression in heterochromatin.