Sylvain Lehmann

This study shows that low-dose exposure to a fungicide mixture in drinking water impairs brain development and induces autism-like behaviors in mouse offspring.

This paper introduces a Bayesian modeling approach to capture population protein dynamics using cohort data, showing its ability to handle inter-individual variability.

This study develops a 3-compartment model to simultaneously analyze protein dynamics in blood plasma and cerebrospinal fluid, including a hidden CNS compartment, and applies it to 69 proteins from a single individual.

This paper develops a reference method for quantifying α-synuclein in CSF using SI-traceable calibration and MRM, showing linearity across three orders of magnitude.

The paper identifies Syndecan-1 as a specific cerebrospinal fluid biomarker for multiple sclerosis, improving diagnostic and prognostic accuracy compared to existing markers.

The paper introduces a proteomics framework to map protein turnover in human cerebrospinal fluid, identifying turnover rates for nearly 200 proteins and revealing relationships between turnover and protein origin.

The paper shows that hyperphosphorylation of tau at T217 in cerebrospinal fluid is specifically linked to amyloid-β pathology in Alzheimer's disease.