Canonical translation factors eIF1A and eIF5B modulate the initiation step of repeat-associated non-AUG translation.
Hayato Ito, Kodai Machida, Yuzo Fujino, Mayuka Hasumi, Soyoka Sakamoto, Yoshitaka Nagai, Hiroaki Imataka, Hideki Taguchi
The paper identifies eIF1A and eIF5B as repressors of C9orf72-mediated RAN translation by showing their omission enhances RAN translation in all reading frames.
Nucleic Acids Research · Sep 23, 2025Peer-reviewedBiochemistry