BiochemistryNucleic Acids ResearchPeer-reviewed
Canonical translation factors eIF1A and eIF5B modulate the initiation step of repeat-associated non-AUG translation.
Hayato Ito, Kodai Machida, Yuzo Fujino…·Hideki Taguchi
The paper identifies eIF1A and eIF5B as repressors of C9orf72-mediated RAN translation by showing their omission enhances RAN translation in all reading frames.
7 citations