Author

Hannah L. Thirman

Vanderbilt UniversityORCID 0000-0002-3735-9995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Abiodun Samuel OyedeleiD· 1 shared Allison S. WalkeriD· 1 shared Cameron I. CoheniD· 1 shared Christine Mae F. AncajasiD· 1 shared Jade M. McDanieliD· 1 shared John A. Jr. PorcoiD· 1 shared Jonathan Michael IrishiD· 1 shared Laura C. GebeniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

Abiodun Samuel OyedeleORCID

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2 papers

Recent·Most cited

Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes

Hannah L. Thirman, Madeline Hayes, Laura C. Geben, Rebecca A. Ihrie, Lauren E. Brown, John A. Jr. Porco, Jonathan Michael Irish

The paper screens a compound library to identify leukemia-selective chemotypes using single-cell profiling and finds that certain rocaglate derivatives selectively induce DNA damage in leukemia cells.

Communications Biology · Jul 31, 2025Peer-reviewedSystems Biology

Statistical Coupling Analysis Predicts Correlated Motions in Dihydrofolate Reductase

Thomas L. Kalmer, Christine Mae F. Ancajas, Cameron I. Cohen, Jade M. McDaniel, Abiodun Samuel Oyedele, Hannah L. Thirman, Allison S. Walker

This study uses statistical coupling analysis and molecular dynamics to show that dynamically coupled residues in DHFR influence evolution and allosteric communication.

The Journal of Physical Chemistry B · Oct 10, 2024Peer-reviewedBiochemistry