Author

Der‐Lii M. Tzou

Institute of Chemistry, Academia SinicaORCID 0000-0002-3755-8230Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:virus· 2 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Kathleen Joyce CarilloiD· 3 shared Hsiao-Jung ChiuiD· 2 shared Louise Tzung-Harn HsiehiD· 2 shared Wen ChangiD· 2 shared Chang Sheng‐Huei LiniD· 1 shared Chun-Hsiung Wang· 1 shared Keiichi NambaiD· 1 shared Petra ŠtěrbováiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

Kathleen Joyce CarilloORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure and functional analyses of vaccinia virus J5 protein reveal distinct determinants for entry-fusion complex assembly and activation

Hsiao-Jung Chiu, Kathleen Joyce Carillo, Louise Tzung-Harn Hsieh, Yuan‐Chao Lou, Chang Sheng‐Huei Lin, Der‐Lii M. Tzou, Wen Chang

This study determines the structure of vaccinia virus J5 protein and identifies key regions for EFC assembly and membrane fusion.

Journal of Virology · Jul 6, 2026Peer-reviewedMicrobiology

Structure and functional analyses of Vaccinia virus entry- fusion complex component J5 protein

Hsiao-Jung Chiu, Louise Tzung-Harn Hsieh, Kathleen Joyce Carillo, Der‐Lii M. Tzou, Wen Chang

The paper determines the NMR structure of J5 protein and identifies functional residues critical for EFC integrity and membrane fusion in Vaccinia virus entry.

bioRxiv · Nov 13, 2025 · PreprintMicrobiology

Cryo-EM inspired NMR analysis reveals a pH-induced conformational switching mechanism for imparting dynamics to Betanodavirus protrusions

Petra Štěrbová, Chun-Hsiung Wang, Kathleen J.D. Carillo, Yuan-Chao Lou, Takayuki Kato, Keiichi Namba, Der-Lii M. Tzou, Wei-Hau Chang

This study reveals a pH-induced conformational switching mechanism in Betanodavirus protrusions that governs infectivity through dynamic structural changes.

bioRxiv · Mar 8, 2024 · PreprintBiochemistry