Wei‐Hau Chang

The paper designs truncated nsp8 proteins to inhibit SARS-CoV-2 replication by disrupting the nsp12-nsp7-nsp8 complex through competitive binding.

The paper investigates the structural dynamics of the tWH domain in RNA polymerase III using smFRET and reveals multiple docking sites that explain its multi-functionality.

This paper identifies a conserved unstructured region in Prp40 WW domains that facilitates their positioning to promote non-canonical intron splicing in yeast.

The paper introduces a robust hierarchical linear model for analyzing cryo-EM maps and atomic structures, showing it can capture atom-specific signal features more accurately than existing methods.

This study reveals a pH-induced conformational switching mechanism in Betanodavirus protrusions that governs infectivity through dynamic structural changes.

This study uses phase plate cryo-EM to reveal conformational diversity in therapeutic IgG, achieving sub-nanometer resolution of the Fab fragment.

RE2DC improves 2D classification in cryo-EM by balancing computational efficiency and robustness, achieving faster processing and better resolution of rare particle populations.