Author

Li Yu

Center for Life SciencesORCID 0000-0002-3757-0758Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Li Yu1 paper · Zhongnan Hospital of Wuhan University

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Boqi LiuiD· 1 shared Dongju WangiD· 1 shared Donglin LiiD· 1 shared Guoqiang YuiD· 1 shared Haifang Wang· 1 shared Hesong ZengiD· 1 shared Hongcheng Jiang· 1 shared Hongjie WangiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperBioinformatics

Boqi LiuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

FOCUS-3D: Robust, generalizable volumetric cell segmentation for three-dimensional fluorescence microscopy

Qinghua Zhang, Zeyu Mu, Boqi Liu, Yunfeng Chi, Donglin Li, Wenjuan Wang, Jian‐Quan Ni, Yinan Wan, Li Yu, Joaquín Navajas Acedo, Guoqiang Yu

FOCUS-3D segments cells in 3D fluorescence microscopy data across species and tissues, revealing phases of notochord morphogenesis in zebrafish.

bioRxiv · Aug 28, 2026 · PreprintBioinformatics

Molecular mechanism of the flotillin complex in membrane microdomain organization

Ming-Ao Lu, Yunwen Qian, Liangwen Ma, Jinzhi Hong, Xiaopeng Li, Li Yu, Qiang Guo, Ning Gao

This study determines the cryo-EM structure of the flotillin complex, revealing its role in membrane microdomain organization and phosphorylation-regulated assembly.

Nature Communications · Feb 9, 2026Peer-reviewedBiochemistry

AT1R and Integrin β3 Synergize to Drive Aortic Dissection via Non-Canonical Wnt/β-Catenin Signaling

Hongcheng Jiang, Zi-Xuan Liu, Li Yu, Xiaodan Zhong, Yunkun Qu, Shiliang Li, Lei Dai, Ying Zhang, Mengwen Wang, Wenjun Zhang, Wanjun Liu, Xingwei He, Wei Dong, Thati Madhusudhan, Zhiyong Li, , Hesong Zeng

This study identifies integrin β3 as a key driver of aortic dissection, showing its synergy with AT1R via non-canonical Wnt/β-catenin signaling, and suggests dual-target therapy as a potential treatment.

bioRxiv · Mar 26, 2025 · PreprintPharmacology & Toxicology

Engineered Migrasomes: Harnessing Core Migrasome Machinery and Hypotonic Shock to Develop a Robust and Thermally Stable Vaccine Platform

Dongju Wang, Haifang Wang, Wei Wan, Zihui Zhu, Takami Sho, Yi Zheng, Xing Zhang, Longyu Dou, Qiang Ding, Li Yu, Zhihua Liu

This study engineers migrasome-like vesicles (eMigrasomes) using hypotonic shock to create a stable, thermally robust vaccine platform that elicits strong immune responses.

bioRxiv · Mar 13, 2024 · PreprintCell Biology