SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages
Zhenlan Yao, Pablo A. Alvarez, Carolina Chavez, Yennifer Delgado, Prashant Kaushal, David Austin, Qian Li, Yanying Yu, Anne K. Zaiss, Vaithilingaraja Arumugaswami, Qiang Ding, Jeffrey J. Hsu, Robert D. Damoiseaux, Hector C. Aguilar, Mehdi Bouhaddou, , Melody M. H. Li
This study shows the SARS-CoV-2 nucleocapsid protein drives hyperinflammation and vascular leakage in macrophages via Toll-like receptor signaling, contributing to severe COVID-19 complications.
Science Advances · Aug 5, 2026Peer-reviewedMicrobiology