Matteo Masetti

Breaking new ground into RAD51-BRC repeats interplay in Homologous Recombination

This study investigates the RAD51-BRC repeats interaction using computational and experimental methods to better understand its role in homologous recombination and its implications for cancer.

Integrative Ensemble Modeling reveals RNA conformations targetable by small molecules

This study uses integrative ensemble modeling to identify RNA conformations that can be targeted by small molecules, revealing ligandable sites not visible in static structures.

Role of Water Models in Simulations of Ion Conduction in Potassium Channels

The paper uses molecular dynamics simulations to show that both hard and soft knock-on mechanisms of ion conduction in potassium channels are accessible and reversible, depending on simulation parameters.

Critical Assessment of a Structure-Based Pipeline for Targeting the Long Non-Coding RNA MALAT1

The paper evaluates a structure-based drug discovery pipeline for targeting MALAT1 using 21 ligands, identifying a binding mode that aligns with experimental affinity trends.

Integrating computational and experimental biophysics reveals novel insights into the RAD51-BRC4 interaction

This study combines computational and experimental methods to characterize the conformational dynamics of the RAD51-BRC4 complex, revealing key residues involved in their interaction.