LUCas: Light-Uncaged Cas13a using photocleavable interfering guide RNAs
Carlos F. Ng, Deepak Krishnamurthy, Andres Dextre, Aymeric Chorlay, Mélanie Ott, Daniel A. Fletcher
This paper introduces LUCas, a light-controlled Cas13a system that suppresses background activity and enables precise control of RNA detection, improving assay sensitivity and enabling multiplexed viral co-infection detection.
Nucleic Acids Research · Aug 17, 2026Peer-reviewedBioengineering