Author

Yiyang Chen

Tisch Cancer InstituteORCID 0000-0002-3795-919XUnclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yiyang Chen2 papers · Ministry of Agriculture and Rural Affairs

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jerry E. ChipukiD· 3 shared Jesse D. GellesiD· 3 shared Ioana Abraham‐Enachescu· 2 shared Jesminara KhatuniD· 2 shared Md Abdullah Al NomaniD· 2 shared Stella G. BayiokosiD· 2 shared Agneesh BaruaiD· 1 shared Ahmed M. ElsaadiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

Jerry E. ChipukORCID

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3 papers

Recent·Most cited

Cancer BiologyAntibodiesPeer-reviewedApr 20, 2026

A Human Recombinant Antibody Against DRP1 Serine 616 Phosphorylation Enables Detection of BRAFV600E-Associated Mitochondrial Division in Cancer

Shanon Nizard, Yiyang Chen, Madhavika N. Serasinghe…·Jerry E. Chipuk

This paper develops a human recombinant antibody (3G11) specific for DRP1-S616 phosphorylation, demonstrating its utility in detecting mitochondrial division in cancer, particularly in BRAFV600E-associated diseases.

DOI 10.3390/antib15020038

humanproteomics

Cell BiologyNature CommunicationsPeer-reviewedFeb 25, 2026

A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function

Jesse D. Gelles, Yiyang Chen, Mark P.A. Luna‐Vargas…·Jerry E. Chipuk

The paper identifies a hydrophobic funnel in BAX that binds 2t-hexadecenal, enhancing BAX activation with BIM, and shows proline 168 regulates this interaction.

2 citations

humanproteomics

Cancer BiologyCell Communication and SignalingPeer-reviewedJan 25, 2025

Metabolic Adaptations To Acute Glucose Uptake Inhibition Converge Upon Mitochondrial Respiration For Leukemia Cell Survival

Monika Komza, Jesminara Khatun, Jesse D. Gelles…·Jerry E. Chipuk

This study shows that leukemia cells rely on increased mitochondrial respiration for survival when glucose uptake is acutely inhibited by KL-11743.

8 citations

humanmetabolomics