Author
Tisch Cancer InstituteORCID 0000-0002-3960-1853Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Zintis Inde, Sebastian Keppler, Jesse D. Gelles…·Kristopher A. Sarosiek
The paper identifies CDL36, a compound that inhibits cell death by preventing mitochondrial outer membrane permeabilization, with potent cytoprotection against doxorubicin-induced toxicity.
Shanon Nizard, Yiyang Chen, Madhavika N. Serasinghe…·Jerry E. Chipuk
This paper develops a human recombinant antibody (3G11) specific for DRP1-S616 phosphorylation, demonstrating its utility in detecting mitochondrial division in cancer, particularly in BRAFV600E-associated diseases.
Jesse D. Gelles, Yiyang Chen, Mark P.A. Luna‐Vargas…·Jerry E. Chipuk
The paper identifies a hydrophobic funnel in BAX that binds 2t-hexadecenal, enhancing BAX activation with BIM, and shows proline 168 regulates this interaction.
Monika Komza, Jesminara Khatun, Jesse D. Gelles…·Jerry E. Chipuk
This study shows that leukemia cells rely on increased mitochondrial respiration for survival when glucose uptake is acutely inhibited by KL-11743.